Comparison of Anesthetic Efficacy of Intranasal Administration of Medetomidine / Ketamine and Diazepam / Ketamine Combinations in New Zealand White Rabbits

This study aimed to determine the anesthetic efficacy of intranasal medetomidine/ketamine and diazepam/ketamine combinations in New Zealand White rabbits. For this purpose, 12 adult rabbits weighing 2.3‐4.1 kg were used by randomly dividing animals into two groups six animals: Medetomidine ‐ Ketamine (MK) Diazepam (DK). Intranasally, medetomidine (0.2 mg kg‐1) ketamine (10 combination was administered MK group and, diazepam (1 DK group. Before 5, 10, 15, 20, 25, 30, 45, 60 minutes after anesthesia, loss, recovery reflexes evaluated. Onset duration surgical total anesthesia time also recorded. Loss shorter compared Respiratory rate, heart SpO2 decreased as expected both but all parameters, especially SpO2, lower comparing These results showed that IN provide depth minor procedures clinical applications could be performed. Although it seems promising considering its practicality efficacy, is clear more detailed studies with are needed before safety these protocols can established.Their use, recommended for routine when considered severely decreased,